E18 to E19 Survival Archived Images-Coronal

The following images are from a coronally-sectioned head of an E19 rat embryo exposed to tritiated thymidine on E18–24 hr survival.  Note the heavily-labeled cells just outside the germinal zones are now mainly in the medial diencephalon and throughout the forebrain.  These are postmitotic young neurons generated ON E18.  Note that the banded labeling is still prominent outside the neocortical neuroepithelium.  Most germinal zones in the brainstem are primitive ependyma, and the entire brainstem is appears nearly as mature as in the adult; scattered heavily labeled cells are most likely proliferating glia.  The cerebellum stands out as an immature structure in the hindbrain.